Genes regulating MHC class I processing of antigen

被引:63
作者
van Endert, PM [1 ]
机构
[1] Hop Necker Enfants Malad, INSERM U25, F-75743 Paris 15, France
关键词
D O I
10.1016/S0952-7915(99)80015-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing.
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页码:82 / 88
页数:7
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