C-H bond functionalizations with palladium(II): intramolecular oxidative annulations of arenes

被引：119

作者：

Ferreira, Eric M. ^{[1
]}

Zhang, Haiming ^{[1
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Arnold & Mabel Beckman Labs Chem Synth, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

TETRAHEDRON | 2008年 / 64卷 / 26期

关键词：

D O I：

10.1016/j.tet.2008.01.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative annulations for the synthesis of carbocycles were developed using a catalytic palladium(II) system. Indoles with pendant olefin tethers were oxidatively cyclized to form annulated products. Electron-rich aromatic systems were also investigated, culminating in the synthesis of benzofurans and dihydrobenzofurans by a similar protocol. These reactions were demonstrated to proceed by an initial C-H bond functionalization event, followed by olefin insertion and beta-hydride elimination. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5987 / 6001

页数：15

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