Imines in Stille-type cross-coupling reactions:: A multicomponent synthesis of α-substituted amides

被引：43

作者：

Davis, JL ^{[1
]}

Dhawan, R ^{[1
]}

Arndtsen, BA ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 05期

关键词：

amides; imines; multicomponent reactions; palladium; Stille reaction;

D O I：

10.1002/anie.200352123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An alternative to nucleophilic chemistry for the construction of α-substituted amides and amine derivatives from imines is provided by the Stille-type coupling of imines with organotin reagents and acid chlorides (see scheme). This Pd-catalyzed reaction is suitable for components with a range of functional groups and has been extended into a four-component-coupling reaction with carbon monoxide. dba = dibenzylideneacetone, RT = room temperature.

引用

页码：590 / 594

页数：5

共 43 条

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