A progressive synthetic strategy for class B synergimycins

被引：6

作者：

Robinson, JL ^{[1
]}

Taylor, RE ^{[1
]}

Liotta, LA ^{[1
]}

Bolla, ML ^{[1
]}

Azevedo, EV ^{[1
]}

Medina, I ^{[1
]}

McAlpine, SR ^{[1
]}

机构：

[1] San Diego State Univ, Dept Chem, San Diego, CA 92182 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

class B; synergimycin; antibiotic; virginiamycin;

D O I：

10.1016/j.tetlet.2004.01.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid substitutions Lit all points in the macrocycle, leading to structurally diverse class B analogs. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2147 / 2150

页数：4

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