Effect of harmane on mononeuropathic pain in rats

被引：11

作者：

Aricioglu, F

Korcegez, E

Ozyalcin, S

机构：

[1] Marmara Univ, Fac Pharm, Dept Pharmacol, TR-81010 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Dept Algol, Istanbul, Turkey

来源：

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES | 2003年 / 1009卷

关键词：

harmane; chronic constriction injury; imidazoline; allodynia;

D O I：

10.1196/annals.1304.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.

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收藏

页码：180 / 184

页数：5

相关论文

共 15 条

[1]

AIRAKSINEN MM, 1981, MED BIOL, V59, P21

[2] CONCENTRATIONS OF THE ENANTIOMERS OF 5-HYDROXYMETHTRYPTOLINE IN MAMMALIAN URINE - IMPLICATIONS FOR INVIVO BIOSYNTHESIS [J].

BECK, O ;

FAULL, KF .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (15) :2636-2639

[3] A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].

BENNETT, GJ ;

XIE, YK .

PAIN, 1988, 33 (01) :87-107

[4] Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury [J].

Fairbanks, CA ;

Schreiber, KL ;

Brewer, KL ;

Yu, CG ;

Stone, LS ;

Kitto, KF ;

Nguyen, HO ;

Grocholski, BM ;

Shoeman, DW ;

Kehl, LJ ;

Regunathan, S ;

Reis, DJ ;

Yezierski, RP ;

Wilcox, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10584-10589

[5]

Fairbanks CA, 1999, J PHARMACOL EXP THER, V290, P403

[6] Moxonidine, a selective imadazoline-α2-adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice [J].

Fairbanks, CA ;

Nguyen, HO ;

Grocholski, BM ;

Wilcox, GL .

ANESTHESIOLOGY, 2000, 93 (03) :765-773

[7] β-carboline binding to imidazoline receptors [J].

Husbands, SM ;

Glennon, RA ;

Gorgerat, S ;

Gough, R ;

Tyacke, R ;

Crosby, J ;

Nutt, DJ ;

Lewis, JW ;

Hudson, AL .

DRUG AND ALCOHOL DEPENDENCE, 2001, 64 (02) :203-208

[8] Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats [J].

Karadag, HC ;

Ulugol, A ;

Tamer, M ;

Ipci, Y ;

Dokmeci, I .

NEUROSCIENCE LETTERS, 2003, 339 (01) :88-90

[9] Alpha-2 and imidazoline receptor agonists - Their pharmacology and therapeutic role [J].

Khan, ZP ;

Ferguson, CN ;

Jones, RM .

ANAESTHESIA, 1999, 54 (02) :146-165

[10] ANALYSIS OF DRUG-INTERACTION BETWEEN INTRATHECAL CLONIDINE AND MK-801 IN PERIPHERAL NEUROPATHIC PAIN RAT MODEL [J].

LEE, YW ;

YAKSH, TL .

ANESTHESIOLOGY, 1995, 82 (03) :741-748