Enhanced effect of clarithromycin on neutrophil function in vitro

被引：8

作者：

Akamatsu, H

Niwa, Y

Sasaki, H

Asada, Y

Horio, T

机构：

[1] Department of Dermatology, Kansai Medical University, Osaka

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1996年 / 24卷 / 02期

关键词：

clarithromycin; neutrophil function; reactive oxygen species; chemotaxis;

D O I：

10.1177/030006059602400202

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O-2(-), H2O2 and OH . levels were significantly increased by clarithromycin at concentrations of 50 mu g/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.

引用

收藏

页码：185 / 189

页数：5

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