An intracellular renin-angiotensin system in neurons: Fact, hypothesis, or fantasy

被引：149

作者：

Grobe, Justin L. ^{[1
]}

Xu, Di ^{[3
]}

Sigmund, Curt D. ^{[1
,2
,4
]}

机构：

[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA

[3] Univ Iowa, Grad Program Genet, Iowa City, IA 52242 USA

[4] Univ Iowa, Ctr Funct Genom Hypertens, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA

来源：

PHYSIOLOGY | 2008年 / 23卷 / 04期

关键词：

D O I：

10.1152/physiol.00002.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The renin-angiotensin system in the brain acts to regulate a number of physiological processes. Evidence suggests that angiotensin peptides may act as neurotransmitters, although their biosynthetic pathways are poorly understood. We review evidence for neuronal production of angiotensin peptides and hypothesize that angiotensin may be synthesized intracellularly in neurons.

引用

页码：187 / 193

页数：7

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