Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system

被引：87

作者：

Li-Weber, M ^{[1
]}

Krammer, PH ^{[1
]}

机构：

[1] DKFZ, German Canc Res Ctr, Tumor Immunol Program G0300, D-69120 Heidelberg, Germany

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 03期

关键词：

apoptosis; cancer; CD95L; transcriptional regulation;

D O I：

10.1016/S1044-5323(03)00030-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD95/CD95L mediated apoptosis is an important mechanism of immune homeostasis. It is instrumental for termination of an immune response and mainly be involved in peripheral tolerance. Dysregulation of the CD95/CD95L system leads to severe diseases. In this review, we present a survey of the role of the CD95/CD95L system in the immune system and, particularly, focus on the signals and transcription factors (NF-AT, Egr, NF-kappaB. AP-1, c-Myc, Nur77, IRFs, SP-1, ALG-4, RORgammat, and CIITA) involved in CD95L expression. It should also be evident from this review that a profound insight into the molecular mechanisms of CD95L activation should allow to explore potential therapeutic means to treat CD95/CD95L-dependent diseases. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：145 / 157

页数：13

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