Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

被引：19

作者：

Aguilar-Jimenez, Wbeimar ^{[1
]}

Zapata, Wildeman ^{[1
,2
]}

Rugeles, Maria T. ^{[1
]}

机构：

[1] Univ Antioquia UdeA, Fac Med, Grp Inmunovirol, Calle 70 52-21, Medellin, Colombia

[2] Univ Cooperat Colombia, Fac Med, Grp Infettare, Medellin, Colombia

来源：

MICROBES AND INFECTION | 2016年 / 18卷 / 7-8期

关键词：

HIV-1; Vitamin D; HIV-1-exposed seronegative individuals (HESNs); Antiviral agents; Natural resistance to HIV-1; MESSENGER-RNA; DEFENSINS; DEFICIENCY; PEPTIDES; VIRUS; LL-37;

D O I：

10.1016/j.micinf.2016.03.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：510 / 516

页数：7

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