Bioenergetics and transmitter release in the isolated nerve terminal

被引：53

作者：

Nicholls, DG ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 10期

关键词：

synaptosome; glutamate; mitochondria; calcium; membrane potential;

D O I：

10.1023/A:1025653805029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isolated nerve terminal ( or synaptosome) is the simplest preparation that allows mitochondrial bioenergetics to be studied in a physiological milieu, as well as facilitating investigation of the protein chemistry and regulation of synaptic vesicle exocytosis and recovery and providing a target for the study of the mechanism of action of numerous neurotoxins. This brief review discusses studies from our laboratory that may have provided some insight into these aspects of nerve terminal function.

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页码：1433 / 1441

页数：9

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