Cancer - Protective packaging for DNA

被引：15

作者：

Downs, JA

Jackson, SP

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Wellcome Trust Canc Res UK Inst, Cambridge CB2 1QR, England

来源：

NATURE | 2003年 / 424卷 / 6950期

关键词：

D O I：

10.1038/424732a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Histone proteins are best known for their structural role in packaging DNA into a compact form. But it seems that one such protein also works as a tumour suppressor, helping to prevent cancer developing.

引用

页码：732 / 734

页数：3

共 12 条

[1] Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors [J].

Bassing, CH ;

Suh, H ;

Ferguson, DO ;

Chua, KF ;

Manis, J ;

Eckersdorff, M ;

Gleason, M ;

Bronson, R ;

Lee, C ;

Alt, FW .

CELL, 2003, 114 (03) :359-370

[2] Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX [J].

Bassing, CH ;

Chua, KF ;

Sekiguchi, J ;

Suh, H ;

Whitlow, SR ;

Fleming, JC ;

Monroe, BC ;

Ciccone, DN ;

Yan, C ;

Vlasakova, K ;

Livingston, DM ;

Ferguson, DO ;

Scully, R ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8173-8178

[3] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].

Celeste, A ;

Fernandez-Capetillo, O ;

Kruhlak, MJ ;

Pilch, DR ;

Staudt, DW ;

Lee, A ;

Bonner, RF ;

Bonner, WM ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2003, 5 (07) :675-U51

[4] Genomic instability in mice lacking histone H2AX [J].

Celeste, A ;

Petersen, S ;

Romanienko, PJ ;

Fernandez-Capetillo, O ;

Chen, HT ;

Sedelnikova, OA ;

Reina-San-Martin, B ;

Coppola, V ;

Meffre, E ;

Difilippantonio, MJ ;

Redon, C ;

Pilch, DR ;

Olaru, A ;

Eckhaus, M ;

Camerini-Otero, RD ;

Tessarollo, L ;

Livak, F ;

Manova, K ;

Bonner, WM ;

Nussenzweig, MC ;

Nussenzweig, A .

SCIENCE, 2002, 296 (5569) :922-927

[5] H2AX haploinsufficiency modifies genomic stability and tumor susceptibility [J].

Celeste, A ;

Difilippantonio, S ;

Difilippantonio, MJ ;

Fernandez-Capetillo, O ;

Pilch, DR ;

Sedelnikova, OA ;

Eckhaus, M ;

Ried, T ;

Bonner, WM ;

Nussenzweig, A .

CELL, 2003, 114 (03) :371-383

[6] DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation [J].

Difilippantonio, MJ ;

Zhu, J ;

Chen, HT ;

Meffre, E ;

Nussenzweig, MC ;

Max, EE ;

Ried, T ;

Nussenzweig, A .

NATURE, 2000, 404 (6777) :510-514

[7] A role for Saccharomyces cerevisiae histone H2A in DNA repair [J].

Downs, JA ;

Lowndes, NF ;

Jackson, SP .

NATURE, 2000, 408 (6815) :1001-1004

[8] H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis [J].

Fernandez-Capetillo, O ;

Mahadevaiah, SK ;

Celeste, A ;

Romanienko, PJ ;

Camerini-Otero, RD ;

Bonner, WM ;

Manova, K ;

Burgoyne, P ;

Nussenzweig, A .

DEVELOPMENTAL CELL, 2003, 4 (04) :497-508

[9] DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 [J].

Fernandez-Capetillo, O ;

Chen, HT ;

Celeste, A ;

Ward, I ;

Romanienko, PJ ;

Morales, JC ;

Naka, K ;

Xia, ZF ;

Camerini-Otero, RD ;

Motoyama, N ;

Carpenter, PB ;

Bonner, WM ;

Chen, JJ ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2002, 4 (12) :993-997

[10] Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development [J].

Gao, YJ ;

Ferguson, DO ;

Xie, W ;

Manis, JP ;

Sekiguchi, J ;

Frank, KM ;

Chaudhuri, J ;

Horner, J ;

DePinho, RA ;

Alt, FW .

NATURE, 2000, 404 (6780) :897-900

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