A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence

被引:77
作者
Edenberg, HJ
Reynolds, J
Koller, DL
Begleiter, H
Bucholz, KK
Conneally, PM
Crowe, R
Goate, A
Hesselbrock, V
Li, TK
Nurnberger, JI
Porjesz, B
Reich, T
Rice, JP
Schuckit, M
Tischfield, JA
Foroud, T
机构
[1] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
[2] SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA
[3] Washington Univ, Sch Med, St Louis, MO USA
[4] Univ Iowa, Sch Med, Iowa City, IA 52242 USA
[5] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA
[6] Univ Connecticut, Sch Med, Farmington, CT USA
关键词
serotonin transporter; functional promoter polymorphism; alcoholism; association study; linkage analysis;
D O I
10.1111/j.1530-0277.1998.tb03704.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.
引用
收藏
页码:1080 / 1085
页数:6
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