Hydrophilic cholesterol-binding molecular imprinted polymers

被引：53

作者：

Zhong, N ^{[1
]}

Byun, HS ^{[1
]}

Bittman, R ^{[1
]}

机构：

[1] CUNY Queens Coll, Dept Chem & Biochem, Flushing, NY 11367 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

基金：

美国国家卫生研究院;

关键词：

cholesterol; cyclodextrin;

D O I：

10.1016/S0040-4039(01)00045-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel hydrophilic molecularly imprinted polymers (MIPs) were prepared using acryloyl-containing hydrophilic monomers (including cholesteryl acrylate (CA) and acryloyl-6-amino-6-deoxy-beta (or gamma)-cyclodextrin). and their steroid-binding properties were analyzed in 2-PrOH by HPLC. The MIPs bound 38-50 mu mol of cholesterol/g, while the corresponding nonimprinted control polymers (containing no CA) bound only 6-9 mu mol cholesterol/g. The sterol-binding selectivity was illustrated with estrone, which was bound by MIPs in the range 5-36 mu mol/g. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1839 / 1841

页数：3

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