A novel means of favorably tipping the balance between cytopathic and regulatory T cells

被引：3

作者：

Waldmann, TA ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2003年 / 19卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(03)00273-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Zheng and coworkers present a strategy to create transplantation tolerance with three critical elements, the combined administration of rapamycin, an agonist IL-2/Fc, and an antagonist mutant IL-15/Fc cytolytic-fusion protein to inhibit cytopathic effects but retain negative regulatory T cells, to permit allograft retention in animal models.

引用

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页码：465 / 466

页数：2

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