Effects of a selective adenosine A(1) receptor antagonist on the development of cyclosporin nephrotoxicity
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Balakrishnan, VS
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UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALESUNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
Balakrishnan, VS
[1
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vonRuhland, CJ
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UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALESUNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
vonRuhland, CJ
[1
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Griffiths, DFR
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UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALESUNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
Griffiths, DFR
[1
]
Coles, GA
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UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALESUNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
Coles, GA
[1
]
Williams, JD
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UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALESUNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
Williams, JD
[1
]
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[1] UNIV WALES COLL MED, CARDIFF ROYAL INFIRM, INST NEPHROL, CARDIFF CF2 1SZ, S GLAM, WALES
1 The clinical application of cyclosporin as an immunosuppressive agent is limited by its nephrotoxicity. 2 The effect of FK453, a selective A(1)-receptor antagonist, administered twice daily to rats at a dose of 100 mg kg(-1) was assessed on the development of nephrotoxicity induced by cyclosporin (10 mg kg(-1) i.p. daily) administered for 14 days. The effects of nifedipine administered twice daily (0.3 mg kg(-1) s.c.) for 14 days, on cyclosporin nephrotoxicity were also studied. 3 Cyclosporin induced a 46.58% and 35.78% decline in glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) respectively and a reduction of 16.69% in filtration fraction (FF). Co-administration of FK453 resulted in falls of 30.5%, 18.59% and 14.7% in GFR, ERPF and FF respectively, the former two significantly less than the falls seen with cyclosporin (CyA) alone (P<0.05 vs CyA, ANOVA). 4 Nifedipine appeared to have a more pronounced protective effect resulting in a decline of only 20.91% in GFR, with no significant change in ERPF (increase of 0.93%) when co-administered with CyA. 5 These observations indicate adenosine plays a minor role in the pathophysiology of CyA nephrotoxicity.
机构:
ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
BARROS, EJG
BOIM, MA
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
BOIM, MA
AJZEN, H
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
AJZEN, H
RAMOS, OL
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
RAMOS, OL
SCHOR, N
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
机构:
ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
BARROS, EJG
BOIM, MA
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
BOIM, MA
AJZEN, H
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
AJZEN, H
RAMOS, OL
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL
RAMOS, OL
SCHOR, N
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ESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZILESCOLA PAULISTA MED, DIV NEPHROL, RUA BOTUCATU 740, BR-04023 SAO PAULO, SP, BRAZIL