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The 870G>A polymorphism of the cyclin D1 gene is not associated with breast cancer

被引：45
作者：
Krippl, P
Langsenlehner, U
Renner, W
Yazdani-Biuki, B
Wolf, G
Wascher, TC
Paulweber, B
Weitzer, W
Leithner, A
Samonigg, H
机构：
[1] Karl Franzens Univ Graz, Dept Internal Med, Div Oncol, Graz, Austria
[2] Karl Franzens Univ Graz, Clin Inst Med & Lab Diagnost, Graz, Austria
[3] Karl Franzens Univ Graz, Dept Radiol, Div Nucl Med, Graz, Austria
[4] Landeskrankenanstalten Salzburg, Dept Internal Med, Salzburg, Austria
[5] Karl Franzens Univ Graz, Dept Orthoped Surg, Graz, Austria
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2003年 / 82卷 / 03期
关键词：
breast cancer; cyclin D1; epidemiology; gene polymorphism; genetics;
D O I：
10.1023/B:BREA.0000004372.20461.33
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A common 870G>A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility. To analyze its role for breast cancer, we determined the CCND1 genotype in 500 breast cancer patients and 500 controls. CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G>A polymorphism is not associated with breast cancer.
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收藏
页码：165 / 168
页数：4
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