Anti-CD20 monoclonal antibodies and their use in adult autoimmune hematological disorders

被引：23

作者：

Dierickx, Daan ^{[1
]}

Delannoy, Andre ^{[2
]}

Saja, Khalid ^{[3
]}

Verhoef, Gregor ^{[1
]}

Provan, Drew ^{[3
]}

机构：

[1] Univ Hosp Leuven, Dept Hematol, B-3000 Louvain, Belgium

[2] Hop Jolimont, Haine St Paul & Clin Univ St Luc, Brussels, Belgium

[3] Barts London Queen Marys Sch Med & Dent, Ctr Hematol, London, England

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2011年 / 86卷 / 03期

关键词：

THROMBOTIC THROMBOCYTOPENIC PURPURA; RED-CELL APLASIA; VERSUS-HOST-DISEASE; CHRONIC LYMPHOCYTIC-LEUKEMIA; TERM-FOLLOW-UP; COLD AGGLUTININ DISEASE; FACTOR-VIII INHIBITORS; LOW-DOSE RITUXIMAB; MINOR HISTOCOMPATIBILITY ANTIGENS; SYSTEMIC-LUPUS-ERYTHEMATOSUS;

D O I：

10.1002/ajh.21939

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune hematological disorders encompass a broad group of hematological conditions characterized by the loss of self-tolerance to a variety of antigens. Despite good response to first-line therapy in the majority of patients, relapses are common, necessitating new and safe therapeutic options. The anti-CD20 monoclonal antibody rituximab has led to substantial improvement in the treatment of malignant and immune-mediated disorders involving B cells. Although experience with rituximab in immune-mediated hematological disorders is rarely supported by randomized trials, there is now substantial experience with rituximab suggesting that anti-CD20 therapy is an effective and well-tolerated alternative to immunosuppressive therapy in these disorders. However, caution is needed based on recent reports describing-sometimes severe-rituximab-related complications. Am. J. Hematol. 86:278-291, 2011. (C) 2010 Wiley-Liss, Inc.

引用

页码：278 / 291

页数：14

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