Proteomics: a technology-driven and technology-limited discovery science

被引：90

作者：

Lee, KH ^{[1
]}

机构：

[1] Cornell Univ, Ithaca, NY 14853 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2001年 / 19卷 / 06期

关键词：

D O I：

10.1016/S0167-7799(01)01639-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An emerging field for the analysis of biological systems is the study of the complete protein complement of the genome, the 'proteome'. There are several complementary tools available for proteome analysis including 2D protein electrophoresis and mass spectrometry. Emerging technologies for proteome analysis include spotted-array-based methods and microfluidic devices. Taken together, these technologies provide a wealth of information that is useful in discovery-based science. However, there are some key limitations of these approaches and new technology is required to be able to fully integrate proteomic information with information obtained about DNA sequence, mRNA profiles and metabolite concentrations into effective models of biological systems.

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页码：217 / 222

页数：6

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