Synthesis of tetrahydrofurans from protected β-hydroxyaldehydes:: Optimization of the alcohol protecting group

被引：16

作者：

Angle, SR ^{[1
]}

Bernier, DS ^{[1
]}

El-Said, NA ^{[1
]}

Jones, DE ^{[1
]}

Shaw, SZ ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(98)00720-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As part of an effort to generalize the synthesis of substituted tetrahydrofurans from protected beta-hydroxy aldehydes, a series of common alcohol protecting groups was screened for compatibility with the methodology. Employing a beta-(triisopropylsilyloxy)aldehyde resulted in a low yield tetrahydrofuran, while the other protecting groups all afforded good yields of tetrahydrofurans. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3919 / 3922

页数：4

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