共 30 条
Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns
被引:109
作者:

Kelly, BL
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机构: Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

Locksley, RM
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机构: Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
机构:
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Immunol Microbiol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
关键词:
D O I:
10.4049/jimmunol.165.6.2982
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The cytokines IL-4, IL-13, and IL-5 are markers for the Th2 subset of effector T cells and are often expressed together. These cytokine genes are organized within 140 kb of orthologous DNA in both mouse and human. Using IL-1-expressing CD4(+) T cell clones derived from F-1 mice, we identified allelic polymorphisms for each of these cytokines and assessed the parental identity of the cytokine mRNAs, Both monoallelic and biallelic expression occurred for each gene and for an additional gene, IL-3, that lies with GM-CSF over 450 kh telomeric on the same chromosome. When coexpressed in T cell clones, IL-4 was expressed from the same allele as IL-13 or IL-5 in 81% of instances. In contrast, there was only 52% concordance of these three cytokines at the allelic level among clones that expressed IL-3, Independent expression of the cytokine alleles occurs commonly in T cells, but the clustered locus encompassing IL-4, IL-13, and IL-5 is subject to coordinate regulation.
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页码:2982 / 2986
页数:5
相关论文
共 30 条
[1]
Functional diversity of helper T lymphocytes
[J].
Abbas, AK
;
Murphy, KM
;
Sher, A
.
NATURE,
1996, 383 (6603)
:787-793

Abbas, AK
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

Murphy, KM
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

Sher, A
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[2]
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
[J].
Agarwal, S
;
Rao, A
.
IMMUNITY,
1998, 9 (06)
:765-775

Agarwal, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA

Rao, A
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Ctr Blood Res, Boston, MA 02115 USA
[3]
FLOW CYTOMETRIC DETERMINATION OF CYTOKINES IN ACTIVATED MURINE T-HELPER LYMPHOCYTES - EXPRESSION OF INTERLEUKIN-10 IN INTERFERON-GAMMA AND IN INTERLEUKIN-4-EXPRESSING CELLS
[J].
ASSENMACHER, M
;
SCHMITZ, J
;
RADBRUCH, A
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
1994, 24 (05)
:1097-1101

ASSENMACHER, M
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY

SCHMITZ, J
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY

RADBRUCH, A
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY UNIV COLOGNE, INST GENET, D-50923 COLOGNE, GERMANY
[4]
Helper T cell differentiation is controlled by the cell cycle
[J].
Bird, JJ
;
Brown, DR
;
Mullen, AC
;
Moskowitz, NH
;
Mahowald, MA
;
Sider, JR
;
Gajewski, TF
;
Wang, CR
;
Reiner, SL
.
IMMUNITY,
1998, 9 (02)
:229-237

Bird, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Brown, DR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Mullen, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Moskowitz, NH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Mahowald, MA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Sider, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Gajewski, TF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Wang, CR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Med, Chicago, IL 60637 USA

Reiner, SL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Med, Chicago, IL 60637 USA Univ Chicago, Dept Med, Chicago, IL 60637 USA
[5]
Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells
[J].
Bix, M
;
Locksley, RM
.
SCIENCE,
1998, 281 (5381)
:1352-1354

Bix, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

Locksley, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[6]
HETEROGENEITY OF SINGLE-CELL CYTOKINE GENE-EXPRESSION IN CLONAL T-CELL POPULATIONS
[J].
BUCY, RP
;
PANOSKALTSISMORTARI, A
;
HUANG, GQ
;
LI, JM
;
KARR, L
;
ROSS, M
;
RUSSELL, JH
;
MURPHY, KM
;
WEAVER, CT
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1994, 180 (04)
:1251-1262

BUCY, RP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

PANOSKALTSISMORTARI, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

HUANG, GQ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

LI, JM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

KARR, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

ROSS, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

RUSSELL, JH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

MURPHY, KM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

WEAVER, CT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233
[7]
SINGLE-CELL ANALYSIS OF CYTOKINE GENE COEXPRESSION DURING CD4(+) T-CELL PHENOTYPE DEVELOPMENT
[J].
BUCY, RP
;
KARR, L
;
HUANG, GQ
;
LI, JM
;
CARTER, D
;
HONJO, K
;
LEMONS, JA
;
MURPHY, KM
;
WEAVER, CT
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (16)
:7565-7569

BUCY, RP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

KARR, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

HUANG, GQ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

LI, JM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

CARTER, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

HONJO, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

LEMONS, JA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

MURPHY, KM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233

WEAVER, CT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT PATHOL,BIRMINGHAM,AL 35233
[8]
IDENTIFICATION OF A COMMON NUCLEOTIDE-SEQUENCE IN THE 3'-UNTRANSLATED REGION OF MESSENGER-RNA MOLECULES SPECIFYING INFLAMMATORY MEDIATORS
[J].
CAPUT, D
;
BEUTLER, B
;
HARTOG, K
;
THAYER, R
;
BROWNSHIMER, S
;
CERAMI, A
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1986, 83 (06)
:1670-1674

CAPUT, D
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021

BEUTLER, B
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021

HARTOG, K
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021

THAYER, R
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021

BROWNSHIMER, S
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021

CERAMI, A
论文数: 0 引用数: 0
h-index: 0
机构: ROCKEFELLER UNIV,MED BIOCHEM LAB,1230 YORK AVE,NEW YORK,NY 10021
[9]
The human granulocyte-macrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer
[J].
Cockerill, PN
;
Bert, AG
;
Roberts, D
;
Vadas, MA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1999, 96 (26)
:15097-15102

Cockerill, PN
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia

Bert, AG
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia

Roberts, D
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia

Vadas, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia Inst Med & Vet Sci, Hanson Ctr Canc Res, Div Human Immunol, Adelaide, SA 5000, Australia
[10]
A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site
[J].
Duncliffe, KN
;
Bert, AG
;
Vadas, MA
;
Cockerill, PN
.
IMMUNITY,
1997, 6 (02)
:175-185

Duncliffe, KN
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA

Bert, AG
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA

Vadas, MA
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA

Cockerill, PN
论文数: 0 引用数: 0
h-index: 0
机构:
INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA INST MED & VET SCI,DIV HUMAN IMMUNOL,HANSON CTR CANC RES,ADELAIDE,SA 5000,AUSTRALIA