Burkholderia is highly resistant to human beta-defensin 3

被引：63

作者：

Sahly, H

Schubert, S

Harder, J

Rautenberg, P

Ullmann, U

Schröder, J

Podschun, R

机构：

[1] Univ Hosp Schleswig Holstein, Dept Med Microbiol & Virol, D-24105 Kiel, Germany

[2] Univ Hosp Schleswig Holstein, Dept Dermatol, Clin Res Unit, D-24105 Kiel, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 05期

关键词：

D O I：

10.1128/AAC.47.5.1739-1741.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC], less than or equal to50 mug/ml), except for Burkholderia cepacia, for all 23 tested strains of which MBCs were >100 mug/ml.

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页码：1739 / 1741

页数：3

相关论文

共 26 条

[1] Antibacterial components in bronchoalveolar lavage fluid from healthy in individuals and sarcoidosis patients [J].

Agerberth, B ;

Grunewald, J ;

Castaños-Velez, E ;

Olsson, B ;

Jörnvall, H ;

Wigzell, H ;

Eklund, A ;

Gudmundsson, GH .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (01) :283-290

[2] Burkholderia cepacia is resistant to the antimicrobial activity of airway epithelial cells [J].

Baird, RM ;

Brown, H ;

Smith, AW ;

Watson, ML .

IMMUNOPHARMACOLOGY, 1999, 44 (03) :267-272

[3] The novel human beta-defensin-3 is widely expressed in oral tissues [J].

Dunsche, A ;

Açil, Y ;

Dommisch, H ;

Siebert, R ;

Schröder, JM ;

Jepsen, S .

EUROPEAN JOURNAL OF ORAL SCIENCES, 2002, 110 (02) :121-124

[4] Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity -: Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction [J].

García, JRC ;

Jaumann, F ;

Schulz, S ;

Krause, A ;

Rodríguez-Jiménez, J ;

Forssmann, U ;

Adermann, K ;

Klüver, E ;

Vogelmeier, C ;

Becker, D ;

Hedrich, R ;

Forssmann, WG ;

Bals, R .

CELL AND TISSUE RESEARCH, 2001, 306 (02) :257-264

[5] Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia [J].

Govan, JRW ;

Deretic, V .

MICROBIOLOGICAL REVIEWS, 1996, 60 (03) :539-+

[6]

Hancock R E, 2001, Lancet Infect Dis, V1, P156, DOI 10.1016/S1473-3099(01)00092-5

[7] Role of membranes in the activities of antimicrobial cationic peptides [J].

Hancock, REW ;

Rozek, A .

FEMS MICROBIOLOGY LETTERS, 2002, 206 (02) :143-149

[8] Host defence (cationic) peptides - What is their future clinical potential? [J].

Hancock, REW .

DRUGS, 1999, 57 (04) :469-473

[9] Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic [J].

Harder, J ;

Bartels, J ;

Christophers, E ;

Schröder, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5707-5713

[10] A peptide antibiotic from human skin [J].

Harder, J ;

Bartels, J ;

Christophers, E ;

Schroder, JM .

NATURE, 1997, 387 (6636) :861-861