Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly: What We Know So Far

被引：71

作者：

Castillo, Jorge J. ^{[1
]}

Beltran, Brady E. ^{[2
]}

Miranda, Roberto N. ^{[3
]}

Paydas, Semra ^{[4
]}

Winer, Eric S. ^{[5
]}

Butera, James N. ^{[5
]}

机构：

[1] Brown Univ, Miriam Hosp, Warren Alpert Med Sch, Div Hematol Oncol, Providence, RI 02906 USA

[2] Hosp Nacl Edgardo Rebagliati Martins, Div Oncol & Radiotherapy, Lima, Peru

[3] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[4] Cukurova Univ, Dept Oncol, Adana, Turkey

[5] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Div Hematol Oncol, Providence, RI 02906 USA

来源：

ONCOLOGIST | 2011年 / 16卷 / 01期

关键词：

EBV; Epstein-Barr virus; Diffuse large B-cell lymphoma; DLBCL; Elderly; Review; NERVOUS-SYSTEM LYMPHOMA; LYMPHOPROLIFERATIVE DISORDERS; HODGKIN LYMPHOMA; JAPANESE POPULATION; DISEASE; EXPRESSION; CHOP; ASSOCIATION; LMP1; TRANSFORMATION;

D O I：

10.1634/theoncologist.2010-0213

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind EBV-driven malignant transformation of B cells, the different EBV latency patterns associated with DLBCL, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity, which is characterized by a suboptimal response to therapy and poor survival rate. The Oncologist 2011; 16: 87-96

引用

页码：87 / 96

页数：10

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