Epigenetic control of recombination in the immune system

被引：21

作者：

Bergman, Yehudit ^{[1
]}

Cedar, Howard ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Dev Biol & Canc Res, IL-91120 Jerusalem, Israel

来源：

SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 06期

基金：

美国国家卫生研究院;

关键词：

DNA methylation; Asynchronous DNA replication; Chromatin accessibility; V(D)J rearrangement; Locus contraction and decontraction; HEAVY-CHAIN GENE; B-CELL DEVELOPMENT; ANTISENSE INTERGENIC TRANSCRIPTION; TISSUE-SPECIFIC ENHANCERS; IG-KAPPA LOCUS; V(D)J RECOMBINATION; ALLELIC EXCLUSION; HISTONE H3; INTRONIC ENHANCER; CPG ISLANDS;

D O I：

10.1016/j.smim.2010.07.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：323 / 329

页数：7

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