Electronic PCR: bridging the gap between genome mapping and genome sequencing

被引：61

作者：

Schuler, GD ^{[1
]}

机构：

[1] NIH, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-7799(98)01232-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A crucial event in the history of the Human Genome Project was the decision to use sequence-tagged sites (STSs) as common landmarks for genomic mapping. Following several years of constructing STS-based maps of ever-increasing detail, the emphasis has recently shifted towards large-scale genomic sequencing. A computational procedure called 'electronic PCR' allows STS landmarks to be revealed as data emerge from the sequencing pipeline, thereby bridging the gap between mapping and sequencing activities.

引用

页码：456 / 459

页数：4

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