PET physiological measurements using constant infusion

被引：66

作者：

Carson, RE ^{[1
]}

机构：

[1] NIH, Warren Grant Magnuson Clin Ctr, PET Dept, Bethesda, MD 20892 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2000年 / 27卷 / 07期

关键词：

constant infusion; equilibrium; receptors; modeling; volume of distribution;

D O I：

10.1016/S0969-8051(00)00138-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A wide range of study designs can be used with positron emission tomography methods to provide quantitative measurements of physiological parameters. While bolus injection of tracer is the conventional approach, use of combined bolus plus constant infusion provides a number of advantages fur receptor binding tracers. Of recent interest is the use of this approach to dynamically follow the displacement of tracer during in vivo changes in neurotransmitter concentrations. This paper provides an overview of the tradeoffs in using bolus/infusion methods versus conventional bolus injection for receptor binding studies. NUCL MED BIOL 27;7:657-660, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：657 / 660

页数：4

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