The antitumor effects of interferon: A personal history

被引：27

作者：

Gresser, Ion ^{[1
]}

机构：

[1] UPMC, Unite 255, INSERM, Ctr Rech Biomed Crodeliers, F-75270 Paris, France

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

interferon; antitumor therapy; interferon and immune system; multiple biologic effects;

D O I：

10.1016/j.biochi.2007.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Early experiments showed that administration of mouse interferon preparations inhibited the development of viral-induced or spontaneous viral associated leukemias in mice. Interferon alpha/beta was also shown to inhibit the growth of transplantable tumors of different origins in all strains of mice tested. The finding that interferon alpha/beta inhibited the growth of sublines of tumors selected for resistance to interferon alpha/beta indicated the role of interferon induced host mechanisms in the antitumor effects observed. The different host antitumor mechanisms and especially the interaction of interferon alpha/beta with the immune system have been briefly discussed. Injection of mice with a neutralizing antibody to interferon alpha/beta demonstrated the essential role of endogenous interferon alpha/beta in the defense of the mouse against the development of syngeneic, allogeneic and xenogeneic tumors. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：723 / 728

页数：6

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