Hormone replacement therapy and lung cancer risk in Chinese

被引:52
作者
Chen, Kuan-Yu
Hsiao, Chin-Fu
Chang, Gee-Chen
Tsai, Yin-Huang
Su, Wu-Chou
Perng, Reury-Perng
Huang, Ming-Shyan
Hsiung, Chao A.
Chen, Chien-Jen
Yang, Pan-Chyr
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Div Pulm Med, Taipei 100, Taiwan
[2] Natl Hlth Res Inst, Div Biostat & Bioinformat, Zhunan, Taiwan
[3] Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan
[4] Chang Gung Mem Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Taipei 10591, Taiwan
[5] Natl Cheng Kung Univ, Dept Internal Med, Div Hematol Oncol, Tainan 70101, Taiwan
[6] Kaohsiung Med Univ Hosp, Dept Internal Med, Taipei, Taiwan
[7] Taipei Vet Gen Hosp, Chest Dept, Taipei, Taiwan
[8] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[9] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan
关键词
lung cancer; hormone replacement therapy; female; smoking; risk factors;
D O I
10.1002/cncr.22987
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies. There is a high female to male ratio in Chinese lung cancer patients, and female patients have different clinicopathological characteristics compared with Western patient populations. The authors investigated whether HRT may reduce lung cancer risk in Taiwan. METHODS. The authors used a case-control study design to investigate 826 women with lung cancer and 531 healthy controls. Personal interviews based on a structured questionnaire were performed to collect information on HRT use of at least 3 months, age, ethnicity, active and passive smoking, exposure to air pollution, cooking or incense fumes, body mass index (BMI), menopause, and family history of cancers. RESULTS. HIRT use was associated with reduced lung cancer risk with a multivariate, adjusted odds ratio of 0.70 (95% CI, 0.53-0.94; P = .019). HRT use was associated with reduced odds ratio of long cancer in all subset analyses stratified by histology, active and passive cigarette smoking, BMI, history of incense burning, cooking, and motorcycle riding, as well as family history of certain cancers. CONCLUSIONS. This study confirmed that HRT is associated with a reduced lung cancer risk. The results appeared to be applicable to Chinese female population groups.
引用
收藏
页码:1768 / 1775
页数:8
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