Testing nanomaterials of unknown toxicity:: An example based on platinum nanoparticles of different shapes

被引：81

作者：

Elder, Alison ^{[1
]}

Yang, Hong

Gwiazda, Roberto

Teng, Xiaowei

Thurston, Sally

He, Hua

Oberdoerster, Guenter

机构：

[1] Univ Rochester, Dept Environm Med, Rochester, NY 14624 USA

[2] Univ Rochester, Dept Chem Engn, Rochester, NY 14627 USA

[3] Univ Calif Santa Cruz, Dept Environm Toxicol, Santa Cruz, CA 95064 USA

[4] Univ Rochester, Dept Biostat, Rochester, NY 14642 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701962

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human endothelial and lung epithelial cells were exposed to nanosized Pt shapes following acellular analyses of their oxidant potential. Despite clear evidence of particle uptake by cells, the Pt nanoparticles were not found to induce cytotoxicity or oxidative stress in either cell type. Results from in vivo respiratory tract exposures suggest that the particles are retained by lung tissue and that minimal-mild lung inflammation results from exposure to the nanosized Pt particles.

引用

页码：3124 / +

页数：7

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