Solid phase synthesis of benzothiazolyl compounds

被引：54

作者：

Mourtas, S ^{[1
]}

Gatos, D ^{[1
]}

Barlos, K ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Patras, Greece

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 11期

关键词：

benzothiazoles; benzothiazole equivalent; solid phase synthesis; trityl resin;

D O I：

10.1016/S0040-4039(01)00109-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)- and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acylaminobenzenethiols were cleaved from the resin by treatment with trifluoroacetic acid solutions in dichloromethane. The 2-N-acyl-aminobenzenethiols released from the resin were cyclised to the corresponding 2-substituted benzothiazoles, by standing in a solution of dithiothreitol in DMF or methanol for 1-3 h at room temperature. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2201 / 2204

页数：4

共 23 条

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[2]

Barlos K, 1996, INT J PEPT PROT RES, V47, P148

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