Serum neopterin levels in spontaneous urticaria and atopic dermatitis

被引：11

作者：

Ciprandi, G. ^{[1
]}

De Amici, M. ^{[2
]}

Berardi, L. ^{[3
]}

Vignini, M. ^{[3
]}

Caimmi, S. ^{[2
]}

Marseglia, A. ^{[2
]}

Marseglia, G. ^{[2
]}

Fuchs, D. ^{[4
]}

机构：

[1] Univ Genoa, Dept Internal Med, Univ Hosp San Martino, I-16126 Genoa, Italy

[2] Univ Pavia, Paediat Clin, Fdn IRCCS Polyclin San Matteo, I-27100 Pavia, Italy

[3] Univ Pavia, Dermatol Clin, Fdn IRCCS Polyclin San Matteo, I-27100 Pavia, Italy

[4] Innsbruck Med Univ, Div Biol Chem, Bioctr, Innsbruck, Austria

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2011年 / 36卷 / 01期

关键词：

D O I：

10.1111/j.1365-2230.2010.03914.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

P>Serum neopterin may be considered a diagnostic marker of the degree of activation of the immune system. This preliminary study was performed to measure serum neopterin levels in patients with acute spontaneous urticaria (ASU), chronic spontaneous urticaria (CSU) and atopic dermatitis (AD). In total, 180 patients [96 men, 84 women; mean age 23.1 years; 41 with spontaneous urticaria (13 ASU and 28 CSU), 48 with AD] and 96 healthy controls were enrolled in the study. Patients with ASU had the highest neopterin levels, and all three groups of patients (ASU, CSU and AD) had higher values than normal subjects. This preliminary study demonstrates that serum neopterin could be a biomarker of immune activation in patients with SU or AD.

引用

页码：85 / 87

页数：3

共 8 条

[1] An update on the genetics of atopic dermatitis: Scratching the surface in 2009 [J].

Barnes, Kathleen C. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) :16-29

[2] Correlation between T-cell and mast cell activity in patients with chronic urticaria [J].

Hidvégi, B ;

Nagy, E ;

Szabó, T ;

Temesvári, E ;

Marschalkó, M ;

Kárpáti, A ;

Horváth, A ;

Gergely, P .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2003, 132 (02) :177-182

[3] Pathogenesis of chronic urticaria [J].

Kaplan, A. P. ;

Greaves, M. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (06) :777-787

[4] Performance of a fully automated quantitative neopterin measurement assay in a routine voluntary blood donation setting [J].

Mayersbach, Peter ;

Fuchs, Dietmar ;

Schennach, Harald .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2010, 48 (03) :373-377

[5] Neopterin as a marker for immune system activation [J].

Murr, C ;

Widner, B ;

Wirleitner, B ;

Fuchs, D .

CURRENT DRUG METABOLISM, 2002, 3 (02) :175-187

[6]

REINHOLD U, 1988, INT ARCH ALLER A IMM, V8, P120

[7] Atopic dermatitis [J].

Williams, HC .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (22) :2314-2324

[8] EAACI/GA2LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria [J].

Zuberbier, T. ;

Asero, R. ;

Bindslev-Jensen, C. ;

Canonica, G. Walter ;

Church, M. K. ;

Gimenez-Arnau, A. ;

Grattan, C. E. H. ;

Kapp, A. ;

Merk, H. F. ;

Rogala, B. ;

Saini, S. ;

Sanchez-Borges, M. ;

Schmid-Grendelmeier, P. ;

Schuenemann, H. ;

Staubach, P. ;

Vena, G. A. ;

Wedi, B. ;

Maurer, M. .

ALLERGY, 2009, 64 (10) :1417-1426

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