Androgen-responsive circular RNA circSMARCA5 is up -regulated and promotes cell proliferation in prostate cancer

被引：187

作者：

Kong, Zhe ^{[1
]}

Wan, Xuechao ^{[1
]}

Zhang, Yalong ^{[1
]}

Zhang, Pu ^{[1
]}

Zhang, Yingyi ^{[2
]}

Zhang, Xiaona ^{[3
,4
]}

Qi, Xiaoxiang ^{[3
,4
]}

Wu, Hai ^{[1
]}

Huang, Jianfeng ^{[3
,4
]}

Li, Yao ^{[1
]}

机构：

[1] Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Changhai Hosp, Dept Oncol, 168 Changhai Rd, Shanghai 200433, Peoples R China

[3] Shanghai Biotechnol Corp, Shanghai 201203, Peoples R China

[4] Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 493卷 / 03期

基金：

中国国家自然科学基金;

关键词：

circRNA; circSMARCA5; Prostate cancer; Androgen-responsive; Proliferation; NONCODING RNA; STATISTICS; BIOMARKER; INVASION;

D O I：

10.1016/j.bbrc.2017.07.162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3' and 5' ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer. (C) 2017 Published by Elsevier Inc.

引用

页码：1217 / 1223

页数：7

共 32 条

[1]

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome [J].