Anti-Mi-2 antibodies

被引：93

作者：

Ghirardello, A

Zampieri, S

Iaccarino, L

Tarricone, E

Bendo, R

Gambari, PF

Doria, A

机构：

[1] Univ Padua, Med Clin, Div Rheumatol, I-35128 Padua, Italy

[2] Univ Padua, Dept Med & Surg Sci, I-35128 Padua, Italy

来源：

AUTOIMMUNITY | 2005年 / 38卷 / 01期

关键词：

D O I：

10.1080/08916930400022681

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Autoantibodies targeting the Mi-2 nuclear antigen represent one of the serologic hallmarks of idiopathic inflammatory myopathies, with a diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Mi-2 antigen is a component of the nuclesome remodeling- deacetylase (NuRD) complex involved in transcription regulation. Anti-Mi-2 antibodies are strongly associated with dermatomyositis (frequency up to 31%) and have a very high positive predictive value for such disease subset. A strong correlation with HLA-DR7 has been demonstrated. At the moment, optimal serologic testing is achieved by ELISA screening on ricombinant Mi-2 antigen and confirmation of positive results on immunoblot.

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页码：79 / 83

页数：5

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