Intrahepatic Cholestasis of Pregnancy

被引:194
作者
Smith, Devin D. [1 ]
Rood, Kara M. [1 ]
机构
[1] Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA
关键词
intrahepatic; cholestasis; pregnancy; bile acid; stillbirth; preterm; SERUM BILE-ACIDS; URSODEOXYCHOLIC ACID; OBSTETRIC CHOLESTASIS; FETAL OUTCOMES; CHOLIC-ACID; PRURITUS; PREVALENCE; MANAGEMENT; OXYTOCIN; EFFICACY;
D O I
10.1097/GRF.0000000000000495
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and management is difficult due to the paucity of data regarding its diagnosis, treatment, and related adverse outcomes. In this article, we review the epidemiology, pathophysiology, risk factors, laboratory findings, complications, treatment, management, and current evidence surrounding intrahepatic cholestasis of pregnancy.
引用
收藏
页码:134 / 151
页数:18
相关论文
共 59 条
[1]
Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype [J].
Abu-Hayyeh, Shadi ;
Papacleovoulou, Georgia ;
Lovgren-Sandblom, Anita ;
Tahir, Mehreen ;
Oduwole, Olayiwola ;
Jamaludin, Nurul Akmal ;
Ravat, Sabiha ;
Nikolova, Vanya ;
Chambers, Jenny ;
Selden, Clare ;
Rees, Myrddin ;
Marschall, Hanns-Ulrich ;
Parker, Malcolm G. ;
Williamson, Catherine .
HEPATOLOGY, 2013, 57 (02) :716-726
[2]
ACOG Committee Opinion, 2019, OBSTET GYNECOL, DOI [10.1097/AOG.0000000000003083, DOI 10.1097/AOG.0000000000003083]
[3]
Bile Acid Determination after Standardized Glucose Load in Pregnant Women [J].
Adams, April ;
Jacobs, Katherine ;
Vogel, Rachel Isaksson ;
Lupo, Virginia .
AJP REPORTS, 2015, 5 (02) :E168-E171
[4]
Intrahepatic cholestasis of pregnancy: Perinatal outcome associated with expectant management [J].
Alsulyman, OM ;
Ouzounian, JG ;
AmesCastro, M ;
Goodwin, TM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1996, 175 (04) :957-960
[5]
[Anonymous], 2011, INTRAHEPATIC CHOLEST
[6]
[Anonymous], 2018, PHYSL GASTROINTESTIN
[7]
Intrahepatic cholestasis of pregnancy: A French prospective study [J].
Bacq, Y ;
Sapey, T ;
Brechot, MC ;
Pierre, F ;
Fignon, A ;
Dubois, F .
HEPATOLOGY, 1997, 26 (02) :358-364
[8]
Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis [J].
Bacq, Yannick ;
Sentilhes, Loic ;
Reyes, Humberto B. ;
Glantz, Anna ;
Kondrackiene, Jurate ;
Binder, Tomas ;
Nicastri, Pier Luigi ;
Locatelli, Anna ;
Floreani, Annarosa ;
Hernandez, Ismael ;
Di Martino, Vincent .
GASTROENTEROLOGY, 2012, 143 (06) :1492-1501
[9]
DIAGNOSTIC VALUE OF SERUM BILE-ACID ESTIMATIONS IN LIVER-DISEASE [J].
BARNES, S ;
GALLO, GA ;
TRASH, DB ;
MORRIS, JS .
JOURNAL OF CLINICAL PATHOLOGY, 1975, 28 (06) :506-509
[10]
Bergasa NV, SEMIN CUTAN MED SURG, DOI [10.1002/hep.27582, DOI 10.1002/HEP.27582]