Mechanism of Nitric Oxide Production in Macrophages Treated with Medicinal Mushroom Extracts (Review)

被引：28

作者：

Huang, Mian ^{[1
]}

Mei, Xiadeng ^{[1
]}

Zhang, Song ^{[1
]}

机构：

[1] S China Normal Univ, Coll Life Sci, Guangzhou 510631, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | 2011年 / 13卷 / 01期

关键词：

medicinal mushrooms; nitric oxide; mushroom extracts; macrophages; inducible NO synthase; NF-kappa B; NF-KAPPA-B; HEME OXYGENASE-1 INDUCTION; RAW; 264.7; MACROPHAGES; PHELLINUS-LINTEUS; MURINE MACROPHAGES; IMMUNOMODULATING POLYSACCHARIDE; TRICHOLOMA-MATSUTAKE; SYNTHASE EXPRESSION; ANTRODIA-CAMPHORATA; ACTIVATION;

D O I：

10.1615/IntJMedMushr.v13.i1.10

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nitric oxide (NO) is a gas with highly reactive radicals and is an important signal molecule in living organisms with diverse pathophysiological functions. Inducible NO synthase (iNOS) can be expressed in macrophages and is able to induce NO production. Studies have proposed that mushroom extracts can promote or inhibit NO production in macrophages through acting on iNOS, nuclear factor kappa B, and other signaling pathways. This article is dedicated to the mechanism of mushroom extracts affecting NO secretion in macrophages.

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页码：1 / 6

页数：6

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