Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification

被引：133

作者：

Aoi, Wataru ^{[1
,2
]}

Naito, Yuji ^{[1
,3
]}

Takanami, Yoshikazu

Ishii, Takeshi ^{[4
]}

Kawai, Yukari ^{[2
]}

Akagiri, Satomi ^{[1
]}

Kato, Yoji ^{[5
]}

Osawa, Toshihiko ^{[6
]}

Yoshikawa, Toshikazu ^{[1
,2
,3
]}

机构：

[1] Kyoto Prefectural Univ Med, Sch Med Sci, Dept Inflammat & Immunol, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Prevent Med Hlth Sci, Kyoto 6028566, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Med Proteom, Kyoto 6028566, Japan

[4] Univ Shizuoka, Lab Func Food Sci, Shizuoka 4228526, Japan

[5] Univ Hyogo, Sch Human Sci & Environm, Lab React Oxygen Species, Hyogo 6700092, Japan

[6] Nagoya Univ, Grad Sch Bioagricultural Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 366卷 / 04期

基金：

日本学术振兴会;

关键词：

astaxanthin; skeletal muscle; lipid metabolism; running exercise; CPT I;

D O I：

10.1016/j.bbrc.2007.12.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular redox balance may affect nutrient metabolism in skeletal muscle. Astaxanthin, a carotenoid contained in various natural foods, exerts hi h antioxidative capacity in the skeletal muscles. The present study investigated the effect of astaxanthin on muscle lipid metabolism in exercise. ICR mice (8 weeks old) were divided into four different groups: sedentary, sedentary treated with astaxanthin, running exercise, and exercise treated with astaxanthin. After 4 weeks of treatment, exercise groups performed treadmill running. Asiaxanthin increased fat utilization during exercise compared with mice on a normal diet with prolongation of the running time to exhaustion. Colocalization of fatty acid translocase with carnitine palmitoyltransferase I (CPT I) in skeletal muscle was increased by astaxanthin. We also found that hexanoyl-lysine modification of CPT I was increased by exercise, while astaxanthin prevented this increase. In additional experiment, we found that astaxanthin treatment accelerated the decrease of body fat accumulation with exercise training. Our results suggested that astaxanthin promoted lipid metabolism rather than glucose utilization during exercise via CPT I activation, which led to improvement of endurance and efficient reduction of adipose tissue with training. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：892 / 897

页数：6

共 34 条

[1] Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice [J].