Structure-activity relationships of novel potent MurF inhibitors

被引：43

作者：

Gu, YG ^{[1
]}

Florjancic, AS ^{[1
]}

Clark, RF ^{[1
]}

Zhang, TY ^{[1
]}

Cooper, CS ^{[1
]}

Anderson, DD ^{[1
]}

Lerner, CG ^{[1
]}

McCall, JO ^{[1
]}

Cai, YN ^{[1
]}

Black-Schaefer, CL ^{[1
]}

Stamper, GF ^{[1
]}

Hajduk, PJ ^{[1
]}

Beutel, BA ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Infect Dis Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.bmcl.2003.09.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC50 = 22 similar to 70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：267 / 270

页数：4

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