Non-professional marathon running: RAGE axis and ST2 family changes in relation to open-window effect, inflammation and renal function

被引：22

作者：

Bekos, Christine ^{[1
,2
]}

Zimmermann, Matthias ^{[1
]}

Unger, Lukas ^{[1
]}

Janik, Stefan ^{[1
]}

Hacker, Philipp ^{[1
]}

Mitterbauer, Andreas ^{[1
]}

Koller, Michael ^{[3
]}

Fritz, Robert ^{[3
]}

Gaebler, Christian ^{[3
]}

Kessler, Mario ^{[4
]}

Nickl, Stefanie ^{[5
]}

Didcock, Jessica ^{[1
]}

Altmann, Patrick ^{[1
]}

Haider, Thomas ^{[1
,6
]}

Roth, Georg ^{[7
]}

Klepetko, Walter ^{[8
]}

Ankersmit, Hendrik Jan ^{[1
,8
]}

Moser, Bernhard ^{[1
,8
]}

机构：

[1] Med Univ Vienna, Christian Doppler Lab Cardiac & Thorac Diag & Reg, Vienna, Austria

[2] Med Univ Vienna, Div Gynaecol & Gynecol Oncol, Dept Obstet & Gynaecol, Vienna, Austria

[3] Sportordination, Alserstr 27-1-6, Vienna, Austria

[4] Austrian Red Cross, Nottendorfer Gasse 21, A-1030 Vienna, Austria

[5] Med Univ Vienna, Div Plast & Reconstruct Surg, Dept Surg, Vienna, Austria

[6] Med Univ Vienna, Dept Trauma Surg, Vienna, Austria

[7] Med Univ Vienna, Dept Anesthesia Crit Care & Pain Med, Vienna, Austria

[8] Med Univ Vienna, Div Thorac Surg, Dept Surg, Vienna, Austria

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

GLYCATION END-PRODUCTS; ACUTE KIDNEY INJURY; CREATINE-KINASE; PLATELET ACTIVATION; POSITION STATEMENT; RISK; BIOMARKERS; EXERCISE; MARKERS; ATHEROSCLEROSIS;

D O I：

10.1038/srep32315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Conflicting data exist on the relevance of marathon (M) and half marathon (HM) running for health. The number of non-professional athletes finishing M and HM events is steadily growing. In order to investigate molecular changes occurring in amateur athletes, we enrolled 70 non-professional runners finishing a single M (34) or HM (36) event at baseline, the finish line and during recovery, and 30 controls. The measurement of the Receptor for Advanced Glycation Endproducts, Interleukin 1 receptor antagonist, ST2 and cytokeratin 18 was combined with molecules measured during clinical routine. Results were analyzed in the light of blood cell analysis, lactate measurements, correction for changes in plasma volume and body composition assessments. There were intrinsic differences in body mass index, abdominal body fat percentage and training time between M and HM runners. C-reactive protein changes in M and HM runners. While soluble RAGE, AGEs and ST2 increased immediately after the race in HM runners, HMGB1 increased in HM and M after the race and declined to baseline after a recovery period. We give insights into the regulation of various molecules involved in physical stress reactions and their possible implications for the cardiovascular system or renal function.

引用

页数：12

共 65 条

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Production of Nε-(carboxymethyl)lysine is impaired in mice deficient in NADPH oxidase -: A role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation [J].