177Lu-EDTMP:: A potential therapeutic bone agent

被引：53

作者：

Ando, A ^{[1
]}

Ando, I ^{[1
]}

Tonami, N ^{[1
]}

Kinuya, S ^{[1
]}

Kazuma, K ^{[1
]}

Kataiwa, A ^{[1
]}

Nakagawa, M ^{[1
]}

Fujita, N ^{[1
]}

机构：

[1] Kanazawa Univ, Sch Hlth Sci, Kanazawa, Ishikawa 920, Japan

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1998年 / 19卷 / 06期

关键词：

D O I：

10.1097/00006231-199806000-00012

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Lutetium-177 (Lu-177) has both beta particle emissions for a therapeutic effect and gamma emissions for imaging. This study was undertaken to synthesize and evaluate Lu-177-EDTMP (ethylenediaminetetramethylene phosphonic acid) as a therapeutic radiopharmaceutical for the palliation of pain from bone metastases. Chelation of Lu-177 to EDTMP was obtained by heating for 30 min in boiling water at pH 8.8, resulting in a radiochemical yield of over 99%. The compound was stable for 20 days without any appreciable dissociation. Biodistribution studies in normal rats indicated selective bone accumulation, showing faster blood clearance, higher bone uptake and higher bone-to-soft tissue ratios than Tc-99(m)-MDP. In conclusion, Lu-177-EDTMP has favourable biological and physical characteristics for the palliative treatment of painful bone metastases. ((C) 1998 Lippincott-Raven Publishers).

引用

页码：587 / 591

页数：5

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