The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo

被引：807

作者：

DeChiara, TM ^{[1
]}

Bowen, DC ^{[1
]}

Valenzuela, DM ^{[1
]}

Simmons, MV ^{[1
]}

Poueymirou, WT ^{[1
]}

Thomas, S ^{[1
]}

Kinetz, E ^{[1
]}

Compton, DL ^{[1
]}

Rojas, E ^{[1
]}

Park, JS ^{[1
]}

Smith, C ^{[1
]}

DiStefano, PS ^{[1
]}

Glass, DJ ^{[1
]}

Burden, SJ ^{[1
]}

Yancopoulos, GD ^{[1
]}

机构：

[1] NYU,MED CTR,MOL NEUROBIOL PROGRAM,NEW YORK,NY 10016

来源：

CELL | 1996年 / 85卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(00)81251-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highly specialized nerve terminal with a complex molecular structure on the postsynaptic muscle surface. The receptors and signaling pathways mediating these inductive interactions are not known. We have generated mice with a targeted disruption of the gene encoding MuSK, a receptor tyrosine kinase selectively localized to the postsynaptic muscle surface. Neuromuscular synapses do not form in these mice, suggesting a failure in the induction of synapse formation. Together with the results of an accompanying manuscript, our findings indicate that MuSK responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for all aspects of synapse formation, including organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.

引用

页码：501 / 512

页数：12

共 65 条

[1]

ERBB3 AND ERBB2/NEU MEDIATE THE EFFECT OF HEREGULIN ON ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN MUSCLE - DIFFERENTIAL EXPRESSION AT THE END-PLATE [J].