Progress, paradox, and potential - Parathyroid hormone research over five decades

被引：76

作者：

Potts, John T. ^{[1
,2
]}

Gardella, Thomas J. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Endocrine Unit, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

SKELETAL BIOLOGY AND MEDICINE, PT B: DISEASE MECHANISMS AND THERAPEUTIC CHALLENGES | 2007年 / 1117卷

关键词：

parathyroid hormone; PTH; AMINO-ACID-SEQUENCE; (PTH)/PTH-RELATED PROTEIN-RECEPTOR; BONE; SELECTIVITY; EXTRACTION; PEPTIDE; BINDING;

D O I：

10.1196/annals.1402.088

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the advent of advances in chemical and molecular biology, the structure of parathyroid hormone (PTH); the related protein, parathyroid-related protein (PTHrP); and their principal receptor (PTH/PTHrP receptor [PTHR1]) were established over recent decades. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand-receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium-deficit states.

引用

页码：196 / 208

页数：13

共 38 条

[1]

[Anonymous], 1991, J BONE MINER RES S2, V6, pS1

[2]

AURBACH GD, 1959, J BIOL CHEM, V234, P3179

[3] Studies of calcium and phosphorus metabolism. V. A study of the bone trabeculae as a readily available reserve supply of calcium. [J].

Bauer, W ;

Aub, JC ;

Albright, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1929, 49 (01) :145-U19

[4]

Bilezikian JP, 2002, J BONE MINER RES, V17, pN2

[5] BOVINE PARATHYROID HORMONE - AMINO ACID SEQUENCE [J].

BREWER, HB ;

RONAN, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (04) :1862-&

[6]

Collip JB, 1925, J BIOL CHEM, V63, P395

[7] Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor:: Selectivity of a modified PTH(1-15) Radioligand for GαS-coupled receptor conformations [J].

Dean, T ;

Linglart, A ;

Mahon, MJ ;

Bastepe, M ;

Jüppner, H ;

Potts, JT ;

Gardella, TJ .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (04) :931-943

[8]

DEAN T, 2007, MOL ENDOCRINOL

[9]

DELEAN A, 1980, J BIOL CHEM, V255, P7108

[10]

DELMAS PD, 2006, ENDOCRINOLOGY, P1751

← 1 2 3 4 →