Cercophorins A-C: Novel antifungal and cytotoxic metabolites from the coprophilous fungus Cercophora areolata

被引:139
作者
Whyte, AC
Gloer, JB
Scott, JA
Malloch, D
机构
[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242
[2] UNIV TORONTO,DEPT BOT,TORONTO,ON M5S 1A1,CANADA
来源
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 08期
关键词
D O I
10.1021/np9603232
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Cercophorins A-C (3-5), three novel isocoumarin derivatives with antifungal and cytotoxic activities, have been isolated from the coprophilous fungus Cercophora areolata (JS 166 = UAMH 7495), a colonist of porcupine dung. Two additional new isocoumarins, decarboxycitrinone (1) and 4-acetyl-8-hydroxy-6-methoxy-5-methylisocoumarin (2), and a known tricothecene mycotoxin, roridin E (6), were also obtained from this species. Compounds 1-6 were isolated from ethyl acetate extracts of mycelia and liquid cultures of C. areolata through bioassay-guided fractionation and are the first metabolites to be reported from a member of the genus Cercophora. Their structures were assigned on the basis of MS, selective INEPT and BD-NMR experiments.
引用
收藏
页码:765 / 769
页数:5
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