Polycomb Group Proteins Set the Stage for Early Lineage Commitment

被引：196

作者：

Surface, Lauren E. ^{[1
]}

Thornton, Seraphim R. ^{[1
]}

Boyer, Laurie A. ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 03期

关键词：

EMBRYONIC STEM-CELLS; TRANSCRIPTIONAL REGULATORY CIRCUITRY; HISTONE METHYLTRANSFERASE ACTIVITY; H3; LYSINE-27; METHYLATION; HOX GENE-EXPRESSION; LONG NONCODING RNAS; REPRESSIVE COMPLEX; TARGET GENES; DEVELOPMENTAL REGULATORS; DNA METHYLATION;

D O I：

10.1016/j.stem.2010.08.004

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Precise control of gene expression patterns is critical for the specification of cellular diversity during metazoan development. Polycomb group (PcG) proteins comprise a class of transcriptional modifiers that have dynamic and essential roles in regulating a number of key processes including lineage commitment. How this is accomplished during mammalian development is incompletely understood. Here, we discuss recent studies in embryonic stem cells (ESCs) that provide critical new insights into how PcG proteins may be targeted to genomic sites as well as the mechanisms by which these regulators influence gene expression and multilineage differentiation in mammals.

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页码：288 / 298

页数：11

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