Toll-like Receptors in Inflammatory Bowel Diseases: A Decade Later

被引：281

作者：

Cario, Elke ^{[1
,2
]}

机构：

[1] Univ Duisburg Essen, Div Gastroenterol & Hepatol, Univ Hosp Essen, Inst Grp 1, D-45147 Essen, Germany

[2] Univ Duisburg Essen, Sch Med, D-45147 Essen, Germany

来源：

INFLAMMATORY BOWEL DISEASES | 2010年 / 16卷 / 09期

关键词：

Toll-like receptor; inflammatory bowel disease; review; innate immunity; host defense; intestinal mucosa; Crohn's disease; ulcerative colitis; INTESTINAL EPITHELIAL-CELLS; PROINFLAMMATORY GENE-EXPRESSION; GENOME-WIDE ASSOCIATION; SEGMENTED FILAMENTOUS BACTERIA; ENDOPLASMIC-RETICULUM STRESS; INNATE IMMUNE-RESPONSES; CROHNS-DISEASE; DENDRITIC CELLS; ULCERATIVE-COLITIS; INTERLEUKIN-10-DEFICIENT MICE;

D O I：

10.1002/ibd.21282

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Differential alteration of Toll-like receptor (TLR) expression in inflammatory bowel disease (IBD) was first described 10 years ago. Since then, studies from many groups have led to the current concept that TLRs represent key mediators of innate host defense in the intestine, involved in maintaining mucosal as well as commensal homeostasis. Recent findings in diverse murine models of colitis have helped to reveal the mechanistic importance of TLR dysfunction in IBD pathogenesis. It has become evident that environment, genetics, and host immunity form a multidimensional and highly interactive regulatory triad that controls TLR function in the intestinal mucosa. Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes in IBD colitis and associated cancer.

引用

页码：1583 / 1597

页数：15

共 201 条

[1] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078

[2] TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells [J].

Abreu, MT ;

Arnold, ET ;

Thomas, LS ;

Gonsky, R ;

Zhou, YH ;

Hu, B ;

Arditi, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) :20431-20437

[3] Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide [J].

Abreu, MT ;

Vora, P ;

Faure, E ;

Thomas, LS ;

Arnold, ET ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1609-1616

[4] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[5] Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease [J].

Alberto, Luis ;

Rodriguez, Garcia ;

Ruigomez, Ana ;

Panes, Julian .

GASTROENTEROLOGY, 2006, 130 (06) :1588-1594

[6] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[7] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[8] ATP drives lamina propria TH17 cell differentiation [J].

Atarashi, Koji ;

Nishimura, Junichi ;

Shima, Tatsuichiro ;

Umesaki, Yoshinori ;

Yamamoto, Masahiro ;

Onoue, Masaharu ;

Yagita, Hideo ;

Ishii, Naoto ;

Evans, Richard ;

Honda, Kenya ;

Takeda, Kiyoshi .

NATURE, 2008, 455 (7214) :808-U10

[9] In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain [J].

Bambou, JC ;

Giraud, A ;

Menard, S ;

Begue, B ;

Rakotobe, S ;

Heyman, M ;

Taddei, FO ;

Cerf-Bensussan, N ;

Gaboriau-Routhiau, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) :42984-42992

[10] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

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