Diabetes increases expression of ICAM after a brief period of cerebral ischemia

被引：30

作者：

Ding, CN

He, QP

Li, PA

机构：

[1] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA

[2] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 161卷 / 1-2期

关键词：

diabetes mellitus; cerebral ischemia; cell adhesion molecules; inflammation; cytokine; hyperglycemia;

D O I：

10.1016/j.jneuroim.2004.12.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The objective of present study was to determine whether leukocyte-endothelial cell adhesive molecule, intercellular cell adhesion molecule-1 (ICAM-1) was increased after ischemia in diabetic rats. The immunohistochemistry of ICAM showed that numbers of ICAM-1 positively stained microvessels in the cortex were markedly increased at 3 days of reperfusion in diabetic, but not in non-diabetic rats. These were further confirmed by Western analysis. Western analyses also showed that interlukin-1 beta (IL-1 beta), but not TNF-alpha, was increased at 3 days of the reperfusion in diabetic rats. The results suggest that inflammatory responses may mediate diabetic hyperglycemia-aggravated brain damage induced by ischemia and reperfusion. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：61 / 67

页数：7

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