Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis

被引：141

作者：

Bauer, Kylynda C. ^{[1
,2
]}

Huus, Kelsey E. ^{[1
,2
]}

Finlay, B. Brett ^{[1
,2
,3
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada

[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V5Z 1M9, Canada

来源：

CELLULAR MICROBIOLOGY | 2016年 / 18卷 / 05期

关键词：

CHAIN FATTY-ACIDS; ANXIETY-LIKE BEHAVIOR; NERVOUS-SYSTEM; INDOLEAMINE 2,3-DIOXYGENASE; NEUROTROPHIC FACTOR; INTESTINAL BARRIER; ENVIRONMENTAL ENTEROPATHY; BACTERIAL TRANSLOCATION; REDUCED ANXIETY; VAGUS NERVE;

D O I：

10.1111/cmi.12585

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The concept of a gut microbiota-brain axis has emerged to describe the complex and continuous signalling between the gut microbiota and host nervous system. This review examines key microbial-derived neuromodulators and structural components that comprise the gut microbiota-brain axis. To conclude, we briefly identify current challenges in gut microbiota-brain research and suggest a framework to characterize these interactions. Here, we propose five emerging hallmarks of the gut microbiota-brain axis: (i) Indistinguishability, (ii) Emergence, (iii) Bidirectional Signalling, (iv) Critical Window Fluidity and (5) Neural Homeostasis.

引用

页码：632 / 644

页数：13

共 138 条

[1]

Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice [J].

Ait-Belgnaoui, A. ;

Colom, A. ;

Braniste, V. ;

Ramalho, L. ;

Marrot, A. ;

Cartier, C. ;

Houdeau, E. ;

Theodorou, V. ;

Tompkins, T. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2014, 26 (04) :510-520

[2]

Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus [J].

Alonso, M ;

Vianna, MRM ;

Izquierdo, I ;

Medina, JH .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2002, 22 (5-6) :663-674

[3]

Early infancy microbial and metabolic alterations affect risk of childhood asthma [J].

Arrieta, Marie-Claire ;

Stiemsma, Leah T. ;

Dimitriu, Pedro A. ;

Thorson, Lisa ;

Russell, Shannon ;

Yurist-Doutsch, Sophie ;

Kuzeljevic, Boris ;

Gold, Matthew J. ;

Britton, Heidi M. ;

Lefebvre, Diana L. ;

Subbarao, Padmaja ;

Mandhane, Piush ;

Becker, Allan ;

McNagny, Kelly M. ;

Sears, Malcolm R. ;

Kollmann, Tobias ;

Mohn, William W. ;

Turvey, Stuart E. ;

Finlay, B. Brett .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (307)

[4]

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer [J].

Bak, Lasse K. ;

Schousboe, Arne ;

Waagepetersen, Helle S. .

JOURNAL OF NEUROCHEMISTRY, 2006, 98 (03) :641-653

[5]

Banks WA, 2001, J PHARMACOL EXP THER, V299, P536

[6]

Delivery of peptides to the brain: Emphasis on therapeutic development [J].

Banks, William A. .

BIOPOLYMERS, 2008, 90 (05) :589-594

[7]

γ-Aminobutyric acid production by culturable bacteria from the human intestine [J].

Barrett, E. ;

Ross, R. P. ;

O'Toole, P. W. ;

Fitzgerald, G. F. ;

Stanton, C. .

JOURNAL OF APPLIED MICROBIOLOGY, 2012, 113 (02) :411-417

[8]

Magnetic resonance imaging monitored acute blood-brain barrier changes in experimental traumatic brain injury [J].

Barzo, P ;

Marmarou, A ;

Fatouros, P ;

Corwin, F ;

Dunbar, J .

JOURNAL OF NEUROSURGERY, 1996, 85 (06) :1113-1121

[9]

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice [J].

Bercik, Premysl ;

Denou, Emmanuel ;

Collins, Josh ;

Jackson, Wendy ;

Lu, Jun ;

Jury, Jennifer ;

Deng, Yikang ;

Blennerhassett, Patricia ;

Macri, Joseph ;

McCoy, Kathy D. ;

Verdu, Elena F. ;

Collins, Stephen M. .

GASTROENTEROLOGY, 2011, 141 (02) :599-U701

[10]

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice [J].

Bercik, Premysl ;

Verdu, Elena F. ;

Foster, Jane A. ;

Macri, Joseph ;

Potter, Murray ;

Huang, Xiaxing ;

Malinowski, Paul ;

Jackson, Wendy ;

Blennerhassett, Patricia ;

Neufeld, Karen A. ;

Lu, Jun ;

Khan, Waliul I. ;

Corthesy-Theulaz, Irene ;

Cherbut, Christine ;

Bergonzelli, Gabriela E. ;

Collins, Stephen M. .

GASTROENTEROLOGY, 2010, 139 (06) :2102-U409

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