From form to function: calcium compartmentalization in dendritic spines

被引：297

作者：

Yuste, R ^{[1
]}

Majewska, A ^{[1
]}

Holthoff, K ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 07期

关键词：

D O I：

10.1038/76609

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dendritic spines compartmentalize calcium, and this could be their I nain function. We review experimental work on spine calcium dynamics. Calcium influx into spines is mediated by calcium channels and by NMDA and AMPA receptors and is followed by fast diffusional equilibration within the spine head. Calcium decay kinetics are controlled by slower diffusion through the spine neck and by spine calcium pumps. Calcium release occurs in spines, although its role is controversial. Finally, the endogenous calcium buffers in spines remain unknown. Thus, spines are calcium compartments because of their morphologies and local influx and extrusion mechanisms. These studies highlight the richness and heterogeneity of pathways that regulate calcium accumulations in spines and the close relationship between the morphology and function of the spine.

引用

页码：653 / 659

页数：7

共 99 条

[1] Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene [J].