Approaches permitting and enhancing motoneuron regeneration after spinal cord, ventral root, plexus and peripheral nerve injuries

被引:25
作者
Carlstedt, T [1 ]
机构
[1] Royal Natl Orthopaed Hosp, PNI Unit, Stanmore HA7 4LP, Middx, England
关键词
D O I
10.1097/00019052-200012000-00012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The motoneuron has a strong ability to regenerate after injury. However, the problems of nerve cell survival after a proximal axotomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity during nerve fibre regrowth interfere with a good functional restitution. Current research has addressed these impediments. New approaches for the management of complicated as well as intraspinal lesions and peripheral nerve trunk injuries are described. Curr Opin Neurol 13:683-686. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:683 / 686
页数:4
相关论文
共 23 条
[1]  
Al-Majed AA, 2000, J NEUROSCI, V20, P2602
[2]   Selective motor hyperreinnervation by using contralateral C-7 motor rootlets in the reconstruction of an avulsion injury of the brachial plexus - Case report [J].
Bertelli, JA ;
Ghizoni, MF .
JOURNAL OF NEUROSURGERY, 1999, 90 (06) :1133-1136
[3]  
BIRCH R, 1998, SURG DISORDERS PERIP, P57
[4]   The use of adenoviral vectors and ex vivo transduced neurotransplants: Towards promotion of neuroregeneration [J].
Blits, B ;
Dijkhuizen, PA ;
Hermens, WTJMC ;
Van Esseveldt, LE ;
Boer, GJ ;
Verhaagen, J .
CELL TRANSPLANTATION, 2000, 9 (02) :169-178
[5]   Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury [J].
Carlstedt, T ;
Anand, P ;
Hallin, R ;
Misra, PV ;
Norén, G ;
Seferlis, T .
JOURNAL OF NEUROSURGERY, 2000, 93 (02) :237-247
[6]   RETURN OF FUNCTION AFTER SPINAL-CORD IMPLANTATION OF AVULSED SPINAL NERVE ROOTS [J].
CARLSTEDT, T ;
GRANE, P ;
HALLIN, RG ;
NOREN, G .
LANCET, 1995, 346 (8986) :1323-1325
[7]   Nerve fibre regeneration across the peripheral-central transitional zone [J].
Carlstedt, T .
JOURNAL OF ANATOMY, 1997, 190 :51-56
[8]   Axon regeneration of spinal motoneurons following a lesion at the cord-ventral root interface [J].
Cullheim, S ;
Carlstedt, T ;
Risling, M .
SPINAL CORD, 1999, 37 (12) :811-819
[9]   MOTONEURONS REINNERVATE SKELETAL-MUSCLE AFTER VENTRAL ROOT IMPLANTATION INTO THE SPINAL-CORD OF THE CAT [J].
CULLHEIM, S ;
CARLSTEDT, T ;
LINDA, H ;
RISLING, M ;
ULFHAKE, B .
NEUROSCIENCE, 1989, 29 (03) :725-733
[10]   Polylactide bioabsorbable polymers for guided tissue regeneration [J].
Giardino, R ;
Fini, M ;
Aldini, NN ;
Giavaresi, G ;
Rocca, M .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1999, 47 (02) :303-308