Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging

被引：37

作者：

Chin, Patrick T. K. ^{[1
,2
]}

Buckle, Tessa ^{[1
,2
]}

de Miguel, Arantxa Aguirre ^{[3
]}

Meskers, Stefan C. J. ^{[3
]}

Janssen, Rene A. J. ^{[3
]}

van Leeuwen, Fijs W. B. ^{[1
,2
]}

机构：

[1] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Diagnost Oncol, Dept Radiol, NL-1066 CX Amsterdam, Netherlands

[2] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Diagnost Oncol, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands

[3] Eindhoven Univ Technol, NL-5600 MB Eindhoven, Netherlands

来源：

BIOMATERIALS | 2010年 / 31卷 / 26期

关键词：

Quantum dots; Dual-emissive particles; Multispectral fluorescence imaging; Sentinel lymph node; Prostate cancer; NEAR-INFRARED FLUORESCENCE; SENTINEL NODE; NANOCRYSTALS; CHEMISTRY; INP; PHOTOLUMINESCENCE; LUMINESCENCE; SURGERY; LIGHT; CDSE;

D O I：

10.1016/j.biomaterials.2010.05.030

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Fluorescence molecular imaging is rapidly increasing its popularity in image guided surgery applications. To help develop its full surgical potential it remains a challenge to generate dual-emissive imaging agents that allow for combined visible assessment and sensitive camera based imaging. To this end, we now describe multispectral InP/ZnS quantum dots (QDs) that exhibit a bright visible green/yellow exciton emission combined with a long-lived far red defect emission. The intensity of the latter emission was enhanced by X-ray irradiation and allows for: 1) inverted QD density dependent defect emission intensity, showing improved efficacies at lower QD densities, and 2) detection without direct illumination and interference from autofluorescence. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6823 / 6832

页数：10

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