A future for transgenic livestock

被引:94
作者
Clark, J [1 ]
Whitelaw, B [1 ]
机构
[1] Roslin Inst, Dept Gene Express & Dev, Roslin EH25 9PS, Midlothian, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1038/nrg1183
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The techniques that are used to generate transgenic livestock are inefficient and expensive. This, coupled with the fact that most agriculturally relevant traits are complex and controlled by more than one gene, has restricted the use of transgenic technology. New methods for modifying the genome will underpin a resurgence of research using transgenic livestock. This will not only increase our understanding of basic biology in commercial species, but might also lead to the generation of animals that are more resistant to infectious disease.
引用
收藏
页码:825 / 833
页数:9
相关论文
共 94 条
[1]  
[Anonymous], 1984, RES DEV AGRIC
[2]   Xenogeneic transplantation [J].
Auchincloss, H ;
Sachs, DH .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :433-470
[3]   LIVESTOCK GENOME MAPS [J].
BEATTIE, CW .
TRENDS IN GENETICS, 1994, 10 (09) :334-338
[4]   Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses [J].
Bitko V. ;
Barik S. .
BMC Microbiology, 1 (1) :1-11
[5]   Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy [J].
Brenner, S ;
Malech, HL .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2003, 1640 (01) :1-24
[6]  
BRIDGE AJ, NATURE GENET, V34, P263
[7]   NO SIMPLE SOLUTION FOR MAKING TRANSGENIC MICE [J].
BRINSTER, RL ;
SANDGREN, EP ;
BEHRINGER, RR ;
PALMITER, RD .
CELL, 1989, 59 (02) :239-241
[8]   A system for stable expression of short interfering RNAs in mammalian cells [J].
Brummelkamp, TR ;
Bernards, R ;
Agami, R .
SCIENCE, 2002, 296 (5567) :550-553
[9]  
Buchschacher Gary L. Jr., 2001, Somatic Cell and Molecular Genetics, V26, P1, DOI 10.1023/A:1021014728217
[10]   NORMAL DEVELOPMENT AND BEHAVIOR OF MICE LACKING THE NEURONAL CELL-SURFACE PRP PROTEIN [J].
BUELER, H ;
FISCHER, M ;
LANG, Y ;
BLUETHMANN, H ;
LIPP, HP ;
DEARMOND, SJ ;
PRUSINER, SB ;
AGUET, M ;
WEISSMANN, C .
NATURE, 1992, 356 (6370) :577-582