Mathematical modelling of magnetically targeted drug delivery

被引：242

作者：

Grief, AD ^{[1
]}

Richardson, G ^{[1
]}

机构：

[1] Univ Nottingham, Sch Math Sci, Nottingham NG7 2RD, England

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

magnetic targeting; drug delivery; shear-induced diffusion; network model; magnetic field design; simulation;

D O I：

10.1016/j.jmmm.2005.02.040

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A mathematical model for targeted drug delivery using magnetic particles is developed. This includes a diffusive flux of particles arising from interactions between erythrocytes in the microcirculation. The model is used to track particles in a vessel network. Magnetic field design is discussed and we show that it is impossible to specifically target internal regions using an externally applied field. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：455 / 463

页数：9

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